AI Article Synopsis
- Extracellular vesicles (EVs) are tiny membrane-bound particles that play a crucial role in communication between cells and reflect the characteristics of their parent cells.
- Recent research emphasizes the role of leukemia EVs in promoting tumor growth and helping cancer cells evade treatments, highlighting the need for deeper investigation.
- This review explores how leukemia EVs impact their surrounding environment, influence blood cell production, and affect the immune system, along with discussing potential EV-based therapies for cancer management.
Article Abstract
Extracellular vesicles (EV) are nano-sized membrane enclosed vehicles that are involved in cell-to-cell communication and carry cargo that is representative of the parent cell. Recent studies have highlighted the significant roles leukemia EVs play in tumor progression, and ways in which they can lead to treatment evasion, thus meriting further investigation. Leukemia EVs are involved in crosstalk between the leukemia cell and its surroundings, transforming it into a cancer favorable microenvironment. Due to the diverse biological content found in leukemia EVs, they have an assortment of effects on the cells they interact with and can be harnessed as candidates for diagnostic and therapeutic treatments. This review focuses on EVs in the context of leukemia and the means by which they modulate their microenvironment, hematopoiesis, and the immune system to facilitate malignancy. We will also address current and prospective EV-based therapeutics.
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| http://dx.doi.org/10.1016/j.leukres.2017.11.011 | DOI Listing |
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