Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. The Legionella quorum sensing (Lqs) system produces and responds to the α-hydroxyketone signaling molecule 3-hydroxypentadecane-4-one (Legionella autoinducer-1, LAI-1). The Lqs system controls the switch between the replicative/non-virulent and the transmissive/virulent phase of L. pneumophila, and it is a major regulator of natural competence, motility and virulence of the pathogen. Yet, beyond gene regulation, LAI-1 also directly affects pathogen-host interactions, since the signaling molecule modulates the migration of eukaryotic cells. Genes encoding Lqs homologues are present in many environmental bacteria, suggesting that α-hydroxyketone signaling is widely used for inter-bacterial as well as inter-kingdom signaling. In this review we summarize recent advances on the characterization of the Lqs system and its role in L. pneumophila-host cell interactions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mib.2017.11.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rapid Icm/Dot T4SS Inactivation Prevents Resuscitation of Heat-Induced VBNC Legionella pneumophila by Amoebae.
Environ Microbiol
January 2025
Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
Legionella pneumophila, the causative agent of Legionnaires' disease, employs the Icm/Dot Type IV secretion system (T4SS) to replicate in amoebae and macrophages. The opportunistic pathogen responds to stress by forming 'viable but non-culturable' (VBNC) cells, which cannot be detected by standard cultivation-based techniques. In this study, we document that L.
View Article and Find Full Text PDFThe Relationship between White Matter Architecture and Language Lateralization in the Healthy Brain.
J Neurosci
December 2024
Departments of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L3 9TA, United Kingdom.
Article Synopsis
- Scientists studied how differences in brain structure might affect language abilities in people.
- They looked at data from 1,040 healthy people to see how the brain's wiring relates to language use.
- The study found that people who rely more on the right side of the brain for language often have different brain connections compared to those who use the left side more, which is typical for most people.
Nitric oxide signaling through three receptors regulates virulence, biofilm formation, and phenotypic heterogeneity of .
mBio
June 2024
Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
Unlabelled: The causative agent of Legionnaires' disease, , is an environmental bacterium, that replicates in macrophages, parasitizes amoeba, and forms biofilms. employs the quorum sensing (Lqs) system and the transcription factor LvbR to control various bacterial traits, including virulence and biofilm architecture. LvbR negatively regulates the nitric oxide (NO) receptor Hnox1, linking quorum sensing to NO signaling.
View Article and Find Full Text PDFAdjusting line quantum sensing to improve leaf area index measurements and estimations in forests.
MethodsX
July 2022
Hydrology and Climatology, Institute of Geography, Heidelberg University, Germany.
Rapid and reliable estimation of leaf area index (LAI), a crucial parameter in process-based models of vegetation cover response, is important in ecological studies. The Beer-Lambert law is widely used to calculate forest LAI, but data collection methods are time-consuming and calculations are often inaccurate. Our objective was to improve the accuracy of Beer-Lambert law-based LAI estimation by employing indirect data collection and location-specific light extinction coefficients ().
View Article and Find Full Text PDFMigration of Acanthamoeba through Legionella biofilms is regulated by the bacterial Lqs-LvbR network, effector proteins and the flagellum.
Environ Microbiol
August 2022
Institute of Medical Microbiology, University of Zürich, Gloriastrasse 30, Zürich, 8006, Switzerland.
The environmental bacterium Legionella pneumophila causes the pneumonia Legionnaires' disease. The opportunistic pathogen forms biofilms and employs the Icm/Dot type IV secretion system (T4SS) to replicate in amoebae and macrophages. A regulatory network comprising the Legionella quorum sensing (Lqs) system and the transcription factor LvbR controls bacterial motility, virulence and biofilm architecture.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!