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Higher serotonin levels among patients with rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis compared to healthy controls assessed by liquid chromatography-tandem mass spectrometry (LC-MS).
Rheumatol Int
January 2025
Department of Rheumatology and Immunology, Jagiellonian University Medical College, Jakubowskiego 2, Kraków, 30-688, Poland.
Growing evidence suggests that serotonin is an important mediator in the cross-talk between immune and bone cells, playing a role in the pathogenesis of various types of inflammatory arthritis (IA). However, the relationship between circulating serotonin and different outcomes in three most prevalent IA - rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA), remains limited and requires further investigation. This study was performed to evaluate variations in serotonin serum levels among RA, PsA, and axSpA and to explore the utility of this biochemical marker in the assessment of disease activity and health status measurements provided by the Multi-Dimensional Health Assessment Questionnaire (MDHAQ).
View Article and Find Full Text PDFTeriflunomide-related development of inverse psoriasis and worsening of pre-existing plaque psoriasis.
Dermatol Online J
August 2024
Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA Department of Dermatology, Tulane University, New Orleans, Louisiana, USA.
Leflunomide can be used in management of psoriatic disease. Leflunomide's active metabolite, teriflunomide, is used in the treatment of multiple sclerosis and has unexpectedly been rarely reported to induce pustular psoriasis. In this report, we present a patient with multiple sclerosis who developed inverse psoriasis after starting teriflunomide.
View Article and Find Full Text PDFPSORIASIS AND MENTAL HEALTH: A PSYCHODERMATOLOGICAL APPROACH WITH AN EMPHASIS ON PSYCHOTHERAPY.
Psychiatr Danub
May 2024
School of Medicine, University of Zagreb, Zagreb, Croatia.
Psoriasis is a multifactorial, inflammatory, chronic disease caused by the complex interaction of genetic and environmental factors, including psychosocial distress. This review reasons the importance of the biopsychosocial model and why it should be considered when treating patients with psoriasis. We aimed to provide current evidence for the psychological etiopathogenesis, psychosocial comorbidities, psychosocial assessment, and psychological therapeutic interventions in psoriasis.
View Article and Find Full Text PDFRole of Vitamin C on methotrexate-induced nephrotoxicity in psoriasis context: A preclinical assessment.
Toxicol Rep
December 2024
Facultad de Químico-Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
Article Synopsis
- Methotrexate (MTX) is commonly used for treating psoriasis but can cause kidney damage, which antioxidants like vitamin C (vitC) might mitigate.
- A study using a mouse model of psoriasis explored how vitC impacts kidney toxicity from high doses of MTX, finding that while vitC can reduce kidney damage, it may worsen skin lesions and kidney injury when combined with IMQ (a psoriasis-inducing agent).
- The findings indicate that vitC could be beneficial for renal protection in psoriasis but should not be used alongside MTX in patients with existing kidney issues.
Methotrexate: Use in the Post Dobbs v. Jackson Era.
J Clin Rheumatol
October 2024
From the Division of Clinical Immunology and Rheumatology, University of Alabama Birmingham, Birmingham, Alabama.
Article Synopsis
- Methotrexate is a commonly prescribed medication for various rheumatic diseases like rheumatoid arthritis and systemic lupus erythematosus, originally developed for cancer treatment in the 1960s and approved for RA in 1988.
- It has been used for medical abortions and can cause serious birth defects, affecting 6%-10% of pregnant women taking it, making its use complex in light of current abortion policies in the U.S. after the Dobbs ruling.
- The Dobbs decision has influenced healthcare providers' and patients' views on methotrexate, suggesting an expanded role for rheumatologists in addressing patients' reproductive health concerns.
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