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http://dx.doi.org/10.3389/fimmu.2017.01555 | DOI Listing |
Am J Transplant
February 2025
Department of Surgery, University of Cambridge, Hills Road, Cambridge, CB2 0QQ. Electronic address:
Front Transplant
January 2025
Transplantation Immunobiology Group, Sydney Medical School, University of Sydney Faculty of Medicine and Health, Sydney, NSW, Australia.
Mass Spectrometry allied with generation of activated alloreactive T cell populations and tetramer screening facilitates the identification of endogenous peptides that are directly recognised in complex with allogeneic Major Histocompatibility class I (MHC I) molecules by alloreactive CD8 T cells. We had previously used this approach for the discovery of immunogenic self-peptides presented by the allomorph H-2K (K). In this study, we identified 22 highly immunogenic self-peptides presented by H-2K (K).
View Article and Find Full Text PDFJ Am Soc Nephrol
July 2024
Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.
Key Points: The estimated composition of immune cells in kidney transplants correlates poorly with the primary rejection categories defined by Banff criteria. Spatial cell distribution could be coupled with a detailed cellular composition to assess causal triggers for allorecognition. Intragraft CD8temra cells showed strong and consistent association with graft failure, regardless of the Banff rejection phenotypes.
View Article and Find Full Text PDFJoint Bone Spine
October 2021
Unité Inserm U1236, Faculté de médecine, Université de Rennes 1, 2, avenue du Pr Léon Bernard, 35043 Rennes, France; CHU de Rennes, Pôle Biologie, Rennes, France. Electronic address:
Front Immunol
November 2017
Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
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