AI Article Synopsis
- Recent studies identified new types of colon tumors in rats treated with carcinogens, prompting a re-evaluation of gut tumor classifications.
- In a study of 408 tumors from 398 Sprague-Dawley rats, 11% were adenomas and 89% were invasive carcinomas, with significant proportions being conventional forms.
- The updated classification now includes various types of adenomas and carcinomas, aligning more closely with human colon neoplasia, thereby enhancing the model's relevance for studying human diseases.
Article Abstract
Background: Recent studies have disclosed novel histological phenotypes of colon tumours in carcinogen-treated rats. The aim of this study was to update the current histological classification of colonic neoplasias in Sprague-Dawley (SD) rats.
Materials And Methods: Archival sections from 398 SD rats having 408 neoplasias in previous experiments were re-evaluated.
Results: Of the 408 colonic neoplasias, 11% (44/408) were adenomas without invasive growth and 89% (364/408) invasive carcinomas. Out of the 44 adenomas, 82% were conventional (tubular or villous), 14% traditional serrated (TSA; with unlocked serrations or with closed microtubules) and 5% gut-associated lymphoid tissue (GALT)-associated adenomas. Out of 364 carcinomas, 57% were conventional carcinomas, 26% GALT carcinomas, 8% undifferentiated, 6% signet-ring cell carcinomas, and 4% traditional serrated carcinomas (TSC). Thus, conventional adenomas, conventional carcinomas and GALT-associated carcinomas predominated (p<0.05).
Conclusion: The updated classification of colonic tumours in SD rats includes conventional adenomas, TSA, GALT-associated adenomas, conventional carcinomas, TSC, GALT-associated carcinomas, signet-ring cell carcinomas and undifferentiated carcinomas. Several of the histological phenotypes reported here are not included in any of the current classifications of colonic tumours in rodents. This updated classification fulfils the requirements for an animal model of human disease, inasmuch as similar histological phenotypes of colon neoplasias have been documented in humans.
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| http://dx.doi.org/10.21873/anticanres.12124 | DOI Listing |
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