Autobiographical memory compromise in Alzheimer's disease: a cognitive and clinical overview.

Geriatr Psychol Neuropsychiatr Vieil

Laboratoire SCALab, UMR CNRS 9193, Université de Lille, CHU Lille, Lille, France.

Published: December 2017

Autobiographical memory refers to memory for personal information. The compromise of autobiographical memory in Alzheimer's disease (AD) results in a loss of knowledge about events and facts that defined the patients' life, and consequently, degradation of their self-knowledge and sense of identity. The compromise of autobiographical memory in AD can be attributed to a diminished subjective experience of memory and a diminished sense of the self. Our review provides a comprehensive overview of cognitive and clinical processes that may be involved in difficulties to retrieve autobiographical memories in Alzheimer's disease. Our review also proposes a theoretical model according to which, the diminished ability to retrieve contextual information and the overgenerality of recall result in a diminished subjective experience of past and future thinking. Besides its theoretical contribution, our review proposes clinical applicability for evaluation and rehabilitation of autobiographical memory in AD.

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http://dx.doi.org/10.1684/pnv.2017.0704DOI Listing

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