This paper presents a highly sensitive flexural plate-wave (FPW)-based microsystem for rapid detection of tetrahydrocannabinol (THC) in human urine. First, a circular-type interdigital transducer (IDT) was integrated with a circular-type silicon-grooved reflective grating structure (RGS) to reduce insertion loss. Then, with lower insertion loss (-38.758 dB), the FPW device was used to develop a novel THC biosensor, and the results reveal that this FPW-THC biosensor has low detection limit (1.5625 ng/mL) and high mass-sensitivity (126.67 cm²/g). Finally, this biosensor was integrated with field-programmable gate array (FPGA) board and discrete components for prototyping a FPW readout system, whose maximum error was 12.378 kHz to ensure that the linearity of detection up to R-square is equal to 0.9992.
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http://dx.doi.org/10.3390/s17122760 | DOI Listing |
Anal Chim Acta
May 2025
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, PR China; Key Laboratory of Modern Agricultural Equipment and Technology (Ministry of Education), Jiangsu University, Zhenjiang, Jiangsu, 212013 PR China. Electronic address:
Background: Hypochlorous acid (HClO) is a crucial disinfectant in the food industry. It can be used to soak perishable foods like vegetables, fruits, eggs, fish, and raw meat before processing and storage, eliminating microorganisms, bacteria, fungi, and pathogens to ensure food safety. HClO also helps preserve vegetables and fruits by reducing ethylene production, delaying rotting, decreasing cell membrane permeability, inhibiting polyphenol oxidase activity, and postponing discoloration.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Laboratory Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: () adheres to the surface of medical devices, forming highly drug-resistant biofilms, which has made the development of novel antibacterial agents against and its biofilms a key research focus. By drug repurposing, this study aims to explore the combinational antimicrobial effects between pinaverium bromide (PVB), a -type calcium channel blocker, and oxacillin (OXA) against .
Methods: Clinical isolates of were collected from January to September 2022 at the Department of Clinical Laboratory of the Third Xiangya Hospital, Central South University.
BMJ Open
March 2025
Division of Paediatric Medicine and Paediatric Outcomes Research Team (PORT), The Hospital for Sick Children, Toronto, Ontario, Canada.
Objectives: Authentic patient and family engagement in child health research is defined as researchers working in partnership with patients and families on all aspects of the research process, including refining the research question, tailoring the intervention, devising study procedures and disseminating study findings. While there is good evidence of a positive impact of patient engagement on the research process, on research teams and on patient partners, there are few empirical data on the impact of patient and family engagement on research quality and dissemination. We conducted a systematic review to compare research quality and dissemination metrics for paediatric randomised controlled trials (RCTs) that engaged patients and families in the research process with trials that did not.
View Article and Find Full Text PDFJ Biol Chem
March 2025
Department of Cell Biology and Physiology and the Center for Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Inward rectifier Kir4.1 potassium channels are abundantly expressed in cells that are important for electrolyte homeostasis. Dysregulation of Kir4.
View Article and Find Full Text PDFAm J Obstet Gynecol
March 2025
Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.
Objective: To assess the diagnostic accuracy of current hysteroscopic criteria compared with histopathological analysis (with or without additional immunohistochemistry) for the detection of chronic endometritis.
Data Sources: MEDLINE, Scopus, SciELO, Embase, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials, LILACS, conference proceedings, and international controlled trials registries were searched without date limit or language restrictions.
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