Objective: To evaluate the safety of trans-nasal percutaneous endoscopic gastrostomy (TPEG) placement for nutrition in patients where oral approach is not possible.
Study Design: Case-series.
Place And Duration Of Study: April 2010 to April 2016 in the Department of Gastroenterology at Liaquat National Hospital, Karachi.
Methodology: Patients underwent trans-nasal PEG placement and were included in this study. Inclusion criteria were either gender of any age and patients referred for PEG tube placement in whom oral PEG tube insertion was not possible. Ultrathin gastroscope (outer diameter of 5.9 mm) was passed through a nostril after assessment and lubrication, the pull technique was used for tube placement. Primary outcome variable of study was the safety of the procedure. The secondary outcome variables were procedure related complications during and 72 hours after the procedure.
Results: TPEG placement was successful in all 46 cases. Thirty-one (67.4%) were males. The mean age was 56.63 ±12.62 years. Dysphagia was the main indication in all cases. Head and neck cancer was the most common indication present in 38 (82.6%) patients. In 36 (78.2%) cases, the procedure was performed under local anesthesia. PEG site infection occurred in one (2.1%) patient.
Conclusion: TPEG is a safe procedure in patients with oro-pharyngeal obstruction, and it should be considered as an alternative approach.
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Laryngoscope
October 2024
Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.
Objectives: Trans-nasal humidified rapid insufflation ventilatory exchange (THRIVE) has demonstrated utility in extending the apneic window in the perioperative setting. Its benefits in facilitating tubeless anesthesia are recognized during elective laryngotracheal surgeries. The use of THRIVE and administering higher fractional inspired oxygen concentrations in laser laryngeal surgery (LLS) remains controversial due to the theoretical risk of airway fires.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
April 2024
Chris O'Brien Lifehouse, Camperdown, NSW Australia.
J Anaesthesiol Clin Pharmacol
April 2023
Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
Respiratory management is an important aspect of care in neuroanesthesia practice for neurosurgical patients. A wide variety of procedures are performed under sedation in the neurosurgical population, and maintaining oxygenation is of paramount importance during these procedures. The high-flow oxygen devices improve arterial oxygenation by providing higher inspiratory oxygen concentration and maintaining higher dynamic positive airway pressure.
View Article and Find Full Text PDFAAPS PharmSciTech
September 2023
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, UP, 226002, India.
Numerous neurodegenerative conditions, such as Alzheimer's, Huntington's, Parkinson's, amyotrophic lateral sclerosis, and glioblastoma multiform are now becoming significant concerns of global health. Formulation-related issues, physiological and anatomical barriers, post-administration obstacles, physical challenges, regulatory limitations, environmental hurdles, and health and safety issues have all hindered successful delivery and effective outcomes despite a variety of treatment options. In the current review, we covered the intranasal route, an alternative strategic route targeting brain for improved delivery across the BBB.
View Article and Find Full Text PDFAsian J Psychiatr
October 2023
Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Hosur Road, Bengaluru, 560029, India. Electronic address:
Objectives: Modified ECT is routinely conducted using face mask (FM) and bag ventilation technique. Trans-nasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) is a novel hands-free insufflation technique that provides oxygenation and prolongs apnoea time. There is limited literature comparing the two techniques.
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