AI Article Synopsis
- The researchers created a method for solvent-free reductive amination using iron pentacarbonyl, eliminating the need for an external hydrogen source.
- This new approach does not require any catalysts or additional additives.
- The reaction is versatile and works well with a variety of substrates, including less reactive compounds like benzophenone, and can handle different functional groups such as bromo, cyano, benzyloxy, pyrimidyl, and styryl.
Article Abstract
We developed solvent-free reductive amination without an external hydrogen source using iron pentacarbonyl as a reducing agent. Neither a catalyst nor any other additives were employed. Various types of substrates are suitable for the reaction, including those with low reactivity, e.g. benzophenone. Among others, the protocol tolerates bromo-, cyano-, benzyloxy-, pyrimidyl and styryl moieties.
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| http://dx.doi.org/10.1039/c7ob02795h | DOI Listing |
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