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| http://dx.doi.org/10.4103/aian.AIAN_169_17 | DOI Listing |
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Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature.
Curr Drug Saf
November 2024
Department of Pharmacology, SRM Medical College Hospital and Research Centre, Kattankulathur, Tamilnadu, India.
Background: Stevens-Johnson Syndrome (SJS) is an infrequent yet severe mucocutaneous reaction that involves less than 10% of the Body Surface Area (BSA). It is predominantly induced by certain medications, including anticonvulsants (e.g.
View Article and Find Full Text PDFThe first reported rare case of carbamazepine-induced malignant hypertension from Nepal: a case report.
Ann Med Surg (Lond)
September 2024
Nepal Medical College and Teaching Hospital, Kathmandu University.
Introduction And Importance: Malignant hypertension is the most severe form of hypertension that may cause life-threatening manifestations. Carbamazepine is an antiepileptic drug primarily used for seizure disorders and trigeminal neuralgia. One of the rarely triggered adverse side effects of carbamazepine is drug-induced malignant hypertension.
View Article and Find Full Text PDFPancytopenia in Carbamazepine Therapy: A Rare and Serious Entity with Simple Prevention.
Int J Appl Basic Med Res
March 2023
Department of Psychiatry, Hamdard Institute of Medical Sciences and Research, New Delhi, India.
Carbamazepine is a commonly used drug in psychiatric settings used for indications such as partial seizures, generalized tonic-clonic seizures, mixed seizure patterns, pain associated with trigeminal neuralgia, acute manic, and mixed manic states. However, this drug comes with its own series of adverse effects such as nausea, vomiting, diarrhea, dizziness, hyponatremia, headaches, and dry mouth. One serious side effect which is rarely documented includes "carbamazepine-induced pancytopenia.
View Article and Find Full Text PDFA highlight on carbamazepine-induced adverse drug reactions in Saudi Arabia: a retrospective medical records-based study.
Naunyn Schmiedebergs Arch Pharmacol
November 2023
Department of Cell Biology, King Faisal Specialist Hospital & Research Centre, Riyadh, 11211, Kingdom of Saudi Arabia.
The link between human leukocyte antigen (HLA) alleles and carbamazepine-induced cutaneous, respiratory, and gastrointestinal adverse drug reactions (ADR) has created a window of opportunity for preventing certain forms of cutaneous adverse drug reactions (cADRs); however, there is not enough data to make pharmacogenomic recommendations that can be implemented globally. The aim of this study is to assess and document carbamazepine-induced adverse reactions among prescribed Saudi/non-Saudi patients. A retrospective chart review was performed for patients who received carbamazepine (CBZ) in the period between 2016 and 2020, in the Kingdom of Saudi Arabia.
View Article and Find Full Text PDFGenotyping for HLA risk alleles versus patch tests to diagnose anti-seizure medication induced cutaneous adverse drug reactions.
Front Pharmacol
November 2022
Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands.
To provide a comparison of genotyping for HLA risk alleles versus patch testing to determine which of these two tests is a better diagnostic tool for cutaneous hypersensitivity reactions caused by anti-seizure medication. A literature study was performed in PubMed to assess the sensitivity and specificity of HLA genotyping and patch tests for identifying anti-seizure medication induced cutaneous hypersensitivity reactions. This study shows that HLA-B*15:02 genotyping shows high sensitivity for carbamazepine-induced SJS/TEN, especially in Han Chinese and Southeast Asian patients (66.
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