Background: Sex is an important determinant of lung capacity and function. This study examined the impact of using non-birth sex on the interpretation of spirometry data in transgender subjects with air-flow obstruction.
Methods: This study was a retrospective analysis of anonymous spirometry data. Eighty adult male and 80 adult female subjects were chosen from the database via random sampling. FVC, FEV, and FEV/FVC were collected and analyzed. Differences in percent of predicted, Z scores, classification of disease severity, and the incidence of a value migrating above or below the lower limit of normal between sex assignments were examined.
Results: For born male subjects, percent of predicted for FVC and FEV were significantly higher when the female sex was used: 100.5% versus 118.5% and 78% versus 91.5%, respectively ( < .001). FEV/FVC Z score was -2.53 for male sex and -2.65 for female sex ( = .004). The presence of obstruction was not affected by sex assignment. Use of non-birth sex moved some FVC and FEV data above the lower limit of normal and improved severity classification in others. For born female subjects, percent of predicted for FVC and FEV were significantly lower when the male sex was used: 102% versus 87.5% and 81.5% versus 70.5%, respectively ( < .001). FEV/FVC Z score was -2.17 for female sex and -2.12 for male sex ( < .001). Six born female subjects had their FEV/FVC normalized when male sex was used. Use of non-birth sex moved some FVC and FEV data below the lower limit of normal and worsened severity classification in others. In total, using the non-birth sex affected spirometry interpretation in 45% of born male subjects and 70% of born female subjects.
Conclusions: In transgender subjects with air-flow obstruction, using non-birth sex to calculate predicted spirometry values may have a significant impact on test interpretation and place these patients at risk for misdiagnosis and inappropriate treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4187/respcare.05586 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Law, Blood, and Custody: Sexual Minority Mothers and Heteronormativity.
J Homosex
April 2024
Law Department, Laval University, Quebec City, Canada.
This article analyzes how couples made up of two mothers redefine their roles when they break up as well as how legal professionals frame the custodial arrangements of these former same-sex couples. To do so, we focus on the case of Quebec, Canada, where parentage equality between mothers was attained as early as in 2002. We rely on individual semi-structured interviews with mothers' ( = 17) and legal professionals' accounts ( = 23) as well as on court records regarding physical custody arrangements.
View Article and Find Full Text PDFSame-sex mothers' experiences of equal treatment, parenting stress and disclosure to offspring: a population-based study of parenthood following identity-release sperm donation.
Hum Reprod
October 2022
Department of Psychology, Umeå University, Umeå, Sweden.
Study Question: What are the experiences of same-sex mothers following identity-release sperm donation regarding equal treatment in society, parenting stress and disclosure to child?
Summary Answer: Mothers predominantly reported equal treatment in society, low levels of parenting stress and early disclosure of the donor conception to the child, and half of the couples had also informed the child of his/her right to obtain the donor's identity.
What Is Known Already: The number of two-mother families is increasing, and previous studies have reported about challenges related to heteronormativity, discrimination and the status of the non-birth mother. Same-sex mothers have been found to disclose the child's donor conception earlier than different-sex parents, but little is known regarding disclosure of the child's right to obtain identifying information about the donor.
Associations between heteronormative information, parental support and stress among same-sex mothers in Sweden-A web survey.
Nurs Open
November 2022
School of Health, Care and Social Welfare, Mälardalen University, Eskilstuna, Sweden.
Aim: The aim was to investigate same-sex mothers' self-assessed experiences of forming a family, and the association between heteronormative information, parental support and parenting stress.
Design: A quantitative, cross-sectional study.
Methods: In a web survey conducted in Sweden in 2019, same-sex mothers (N = 146) with a child aged 1-3 years answered questions about their experiences of forming a family through assisted reproduction and questions about parenting stress.
Age- and risk factor-based serologic screening for Hepatitis C virus among an Urban, high-risk population.
J Viral Hepat
December 2020
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Hepatitis C virus (HCV) screening among individuals born between 1945 and 1965 (ie birth cohort) may augment risk factor-based screening. We assessed HCV seropositivity among injection drug users (IDUs) and birth cohort members from New York City. We assessed HCV risk factors and seropositivity in 7722 participants from community health, HIV prevention, syringe exchange and drug treatment programmes.
View Article and Find Full Text PDFThe Impact of Using Non-Birth Sex on the Interpretation of Spirometry Data in Subjects With Air-Flow Obstruction.
Respir Care
February 2018
Departments of Pulmonary, Sleep, and Critical Care Medicine, Kaiser Permanente, Tacoma, Washington.
Background: Sex is an important determinant of lung capacity and function. This study examined the impact of using non-birth sex on the interpretation of spirometry data in transgender subjects with air-flow obstruction.
Methods: This study was a retrospective analysis of anonymous spirometry data.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!