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Tension, contraction and tissue morphogenesis. | LitMetric

Tension, contraction and tissue morphogenesis.

Development

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA

Published: December 2017

D'Arcy Thompson was a proponent of applying mathematical and physical principles to biological systems, an approach that is becoming increasingly common in developmental biology. Indeed, the recent integration of quantitative experimental data, force measurements and mathematical modeling has changed our understanding of morphogenesis - the shaping of an organism during development. Emerging evidence suggests that the subcellular organization of contractile cytoskeletal networks plays a key role in force generation, while on the tissue level the spatial organization of forces determines the morphogenetic output. Inspired by D'Arcy Thompson's , we review our current understanding of how biological forms are created and maintained by the generation and organization of contractile forces at the cell and tissue levels. We focus on recent advances in our understanding of how cells actively sculpt tissues and how forces are involved in specific morphogenetic processes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769629PMC
http://dx.doi.org/10.1242/dev.151282DOI Listing

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