The rescue of botanical insecticides: A bioinspiration for new niches and needs.

Crop protection is the basis of plant production and food security. Additionally, there are many efforts focused on increasing defensive mechanisms in order to avoid the damaging effects of insects, which still represent significant losses worldwide. Plants have naturally evolved different mechanisms to discourage herbivory, including chemical barriers such as the induction of defensive proteins and secondary metabolites, some of which have a historical link with bio-farming practices and others that are yet to be used. In the context of global concern regarding health and environmental impacts, which has been translated into political action and restrictions on the use of synthetic pesticides, this review deals with a description of some historical commercial phytochemicals and promising proteinaceous compounds that plants may modulate to defeat insect attacks. We present a broader outlook on molecular structure and mechanisms of action while we discuss possible tools to achieve effective methods for the biological control of pests, either by the formulation of products or by the development of new plant varieties with enhanced chemical defenses.