AI Article Synopsis
- Since 2008, there have been global outbreaks of atypical hand, foot, and mouth disease (HFMD), primarily caused by a more severe strain of Coxsackie virus A6 (CV-A6).
- Between June 2014 and January 2016, 23 cases of atypical HFMD were noted at a Denmark hospital, with many misdiagnosed as other skin conditions.
- The study highlighted the rise of atypical HFMD in Southern Denmark and emphasized the challenges in diagnosing it due to its similarities with other serious skin diseases.
Article Abstract
Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CV-A16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a Dermatology Department at a regional University Hospital in Denmark. Patients were referred by general practitioners and dermatologists with a variety of clinical diagnoses, including eczema herpeticum, vasculitis, syphilis, dermatophytid, erythema multiforme and Stevens-Johnson syndrome. Three adults and 3 children required hospitalization due to extensive skin involvement and fever. All reported patients had laboratory-confirmed enterovirus infection. This study demonstrated an upsurge in atypical HFMD caused by CV-A6 in the Region of Southern Denmark and that atypical HFMD can be difficult to diagnose clinically as it may mimic other severe skin diseases.
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| http://dx.doi.org/10.2340/00015555-2853 | DOI Listing |
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