AI Article Synopsis
- - The study investigates the relationship between a hormone called irisin and thyroid dysfunction in rats, aiming to see how conditions like hypothyroidism and hyperthyroidism affect irisin levels.
- - Adult male Sprague-Dawley rats were divided into groups to either induce thyroid dysfunction (hypo or hyper) or serve as controls, with blood samples taken afterward to measure hormone levels.
- - Results indicated that both hypothyroidism and hyperthyroidism resulted in increased irisin levels, but when treated appropriately, these levels normalized, highlighting the hormone's role in thyroid health.
Article Abstract
Background A recently discovered hormone, irisin is accepted to be significantly involved in the regulation of body weight. Thyroid functions may be, directly or indirectly, associated with irisin. Aim The aim of the present study is to determine the effect of experimental thyroid dysfunction on irisin levels in rats. Methods The study registered 40 adult male Sprague-Dawley rats, which were allocated to groups as follows: 1. Control; 2. Hypothyroidism induced by injection of 10 mg/kg/day intraperitoneal propylthiouracil (PTU) for 3 weeks; 3. Hypothyroidism (PTU 2 weeks) + L-thyroxin (1.5 mg/kg/day for 1 week); 4. Hyperthyroidism induced in rats by 3-week thyroxin (0.3 mg/kg/day); 5. Hyperthyroidism + PTU. At the end of the study, blood samples were collected to quantify free triiodothyronine (FT3), free triiodothyronine (FT4) and irisin levels. Results FT3 and FT4 levels were reduced in hypothyroidism and were significantly elevated in hyperthyroidism (p < 0.001). Irisin values, on the other hand, were found to be elevated in both hypothyroidism and hyperthyroidism groups (p < 0.001). Conclusion The results of the study suggest that irisin values increase in thyroid dysfunction, hypo- and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal.
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| http://dx.doi.org/10.1515/hmbci-2017-0054 | DOI Listing |
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- Physical activity enhances liver health and reduces oxidative stress, potentially through the protein irisin, with the study focusing on the gene/protein HSP70 and miR-223a in the context of endurance exercise and irisin injection.
- A total of 21 mice were divided into three groups (control, endurance training, irisin injection) to analyze gene and protein expression using techniques like real-time PCR and Western blot analysis over an 8-week period.
- Results showed significant increases in HSP70 expression and serum irisin levels in both the endurance and irisin groups, while miR-223a levels decreased, suggesting that irisin injection could effectively mimic the benefits of prolonged endurance exercise.
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