Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686383 | PMC |
| http://dx.doi.org/10.18240/ijo.2017.11.25 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic and Strains?
Int J Mol Sci
December 2024
Department of Biology and Medical Parasitology, Faculty of Medicine, Wrocław Medical University, Mikulicza-Radeckiego 9, 50-345 Wroclaw, Poland.
Multidrug-resistant bacteria represent a significant challenge in the treatment of bacterial infections, often leading to therapeutic failures. This issue underlines the need to develop strategies that improve the efficacy of conventional antibiotic therapies. In this study, we aimed to assess whether a plant-derived compound, α-mangostin, and photodynamic therapy (PDT) could enhance the antibacterial activity of ciprofloxacin against uropathogenic strains of and .
View Article and Find Full Text PDFDeveloping Allosteric Chaperones for -Associated Disorders-An Integrated Computational and Experimental Approach.
Int J Mol Sci
December 2024
Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, 08028 Barcelona, Spain.
Mutations in the gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are associated with Gaucher disease and increased risk of Parkinson's disease. This study describes the discovery and characterization of novel allosteric pharmacological chaperones for GCase through an innovative computational approach combined with experimental validation. Utilizing virtual screening and structure-activity relationship optimization, researchers identified several compounds that significantly enhance GCase activity and stability across various cellular models, including patient-derived fibroblasts and neuronal cells harboring mutations.
View Article and Find Full Text PDFThe Influence of the Addition of Microsilica and Fly Ash on the Properties of Ultra-High-Performance Concretes.
Materials (Basel)
December 2024
Institute of Optoelectronics, Military University of Technology, 00-908 Warsaw, Poland.
The paper presents experimental studies on the influence of a simultaneous, appropriately proportioned combination of microsilica and fly ash additives on the physical and mechanical properties of ultra-high-performance concretes (UHPCs). Concrete mixtures with the addition of microsilica in the amount of 6.7-14.
View Article and Find Full Text PDFPoly(sodium styrene sulfonate)-Grafted SiO Nanoparticle: Synthesis and Use as a Water-Insoluble Dispersant for Coal Water Slurry.
Polymers (Basel)
December 2024
Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science and Technology, Xi'an 710021, China.
This study introduces a novel water-insoluble dispersant for coal water slurry (CWS), namely, a poly(sodium styrene sulfonate)- SiO nanoparticle (SiO--PSSNa). SiO--PSSNa was synthesized by combining the surface acylation reaction with surface-initiated atom transfer radical polymerization (SI-ATRP). Fourier transform infrared spectrometry (FTIR), X-ray photoelectron spectroscopy (XPS), energy dispersive spectrometer (EDS), nuclear magnetic resonance spectroscopy (NMR) and thermogravimetric analysis (TGA) verified that SiO--PSSNa with the desired structure was successfully obtained.
View Article and Find Full Text PDFCaffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology.
Molecules
January 2025
Department of Experimental Dermatology and Cosmetology, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Krakow, Poland.
Caffeine has recently attracted attention as a potential remedy for hair loss. In the present review, we look into the molecule's possible mechanisms of action and pharmacodynamics. At the molecular level, it appears that the physiological effects of caffeine are mainly due to the molecule's interaction with adenosine pathways which leads to an increase in cAMP level and the stimulation of metabolic activity in the hair follicle.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!