Vibrio cholerae colonizes the human terminal ileum to cause cholera, and the arthropod intestine and exoskeleton to persist in the aquatic environment. Attachment to these surfaces is regulated by the bacterial quorum-sensing signal transduction cascade, which allows bacteria to assess the density of microbial neighbours. Intestinal colonization with V. cholerae results in expenditure of host lipid stores in the model arthropod Drosophila melanogaster. Here we report that activation of quorum sensing in the Drosophila intestine retards this process by repressing V. cholerae succinate uptake. Increased host access to intestinal succinate mitigates infection-induced lipid wasting to extend survival of V. cholerae-infected flies. Therefore, quorum sensing promotes a more favourable interaction between V. cholerae and an arthropod host by reducing the nutritional burden of intestinal colonization.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260827 | PMC |
| http://dx.doi.org/10.1038/s41564-017-0065-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
LitR and its quorum-sensing regulators modulate biofilm formation by .
J Bacteriol
January 2025
Department of Microbiology and Immunology, Stritch School of Medicine Loyola University Chicago, Chicago, Illinois, USA.
Quorum sensing controls numerous processes ranging from the production of virulence factors to biofilm formation. Biofilms, communities of bacteria that are attached to one another and/or a surface, are common in nature, and when they form, they can produce a quorum of bacteria. One model system to study biofilms is the bacterium , which forms a biofilm that promotes the colonization of its symbiotic host.
View Article and Find Full Text PDFBioorganic compounds in quorum sensing disruption: strategies, Mechanisms, and future prospects.
Bioorg Chem
January 2025
Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613401, India. Electronic address:
Recent research has shed light on the complex world of bacterial communication through quorum sensing. This sophisticated intercellular signalling mechanism, driven by auto-inducers, regulates crucial bacterial community behaviours such as biofilm formation, expression of virulence factors, and resistance mechanisms. The increasing threat of antibiotic resistance, coupled with quorum sensing mediated response, necessitates alternative strategies to combat bacterial infections.
View Article and Find Full Text PDFA novel separated OPECT aptasensor based on MOF-derived BiVO/BiS type-II heterojunction for rapid detection of bacterial quorum sensing signal molecules.
Talanta
January 2025
Qingdao Key Laboratory of Analytical Technology Development and Offshore Eco-Environment Conservation, Marine Bioresource and Environment Research Center, First Institute of Oceanography, Ministry of Natural Resources, No. 6 Xianxialing Road, Qingdao, 266061, PR China. Electronic address:
Quorum sensing signal molecules released by microorganisms serve as critical biomarkers regulating the attachment and aggregation of marine microbes on engineered surfaces. Hence, the development of efficient and convenient methods for detecting quorum sensing signal molecules is crucial for monitoring and controlling the formation and development of marine biofouling. Advanced optoelectronic technologies offer increased opportunities and methods for detecting quorum sensing signal molecules, thereby enhancing the accuracy and efficiency of detection.
View Article and Find Full Text PDFLithium enhanced plasmid-mediated conjugative transfer of antimicrobial resistance genes in Escherichia coli: Different concentrations and mechanisms.
Aquat Toxicol
January 2025
Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China. Electronic address:
Conjugative transfer, a pivotal mechanism in the transmission of antimicrobial resistance genes, is susceptible to various environmental pollutants. As an emerging contaminant, lithium (Li) has garnered much attention due to its extensive applications. This research investigated the effects of Li on conjugative transfer process, examining biochemical and omics perspectives.
View Article and Find Full Text PDFc-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in .
mSphere
January 2025
School of Medicine, Southern University of Science and Technology, Shenzhen, China.
The universal bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) plays critical roles in regulating a variety of bacterial functions such as biofilm formation and virulence. The metabolism of c-di-GMP is inversely controlled by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs). Recently, increasing studies suggested that the protein-protein interactions between DGCs/PDEs and their partners appear to be a common way to achieve specific regulation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!