Mitochondrial DNA (mtDNA) is more vulnerable to mutations and associated with many solid tumors. Through mtDNA sequencing, we can find useful information on the mutations implicated in diseases and can better define the impact of mitochondrial dysfunction on the process of carcinogenesis. In current article, we will discuss the current approaches of mtDNA sequencing and the challenges we should overcome, their applications in various cancers, and the potential bioethics problems we should face in the application of mtDNA sequencing in clinical diagnosis and treatment.
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