Activity of hemantane, an amino adamantane derivative, exhibiting the properties of lowaffinity non-competitive NMDA receptor antagonist, was evaluated in experimental in vivo models of alcoholism. Hemantane had no effects on the formation and manifestation of behavioral sensitization to ethanol in DBA/2 mice. Under conditions of free choice between 10% ethanol and water, hemantane (20 mg/kg/day for 14 days, intraperitoneally) significantly reduced the daily ethanol intake in random-bred male rats with formed alcohol motivation (>4 g/kg of ethanol). During modelling of withdrawal syndrome, hemantane administered intraperitoneally in doses of 5-20 mg/kg dose-dependently attenuated alcohol-deprivation effect after acute withdrawal with no effects on protracted abstinence. It was found that hemantane suppressed alcohol drinking behavior in long-term ethanol experienced rats and attenuated alcohol-seeking behavior after acute withdrawal.
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Article Synopsis
- NMDA receptors, which are activated by glutamate, are essential for learning and memory, and memantine (MEM) is used to manage symptoms in Alzheimer’s but may also have cognitive benefits in healthy individuals.
- A study on male rats tested MEM's effects on working memory through a T-maze task, finding that MEM improved performance, especially in those with initially poorer memory skills.
- Neurochemical analysis revealed that certain protein expressions in brain regions were linked to task performance, indicating that the benefits of MEM could depend on an individual’s baseline working memory capability.
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