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Abnormalities of Lipoprotein Levels in Liver Cirrhosis: Clinical Relevance. | LitMetric

Abnormalities of Lipoprotein Levels in Liver Cirrhosis: Clinical Relevance.

Dig Dis Sci

Department of Clinical and Experimental Medicine, Garibaldi Hospital, University of Catania, Via Palermo, 636, 95122, Catania, Italy.

Published: January 2018

AI Article Synopsis

Article Abstract

Progressive lipoprotein impairment occurs in liver cirrhosis and is associated with increased morbidity and mortality. The present review aims to summarize the current evidence regarding the prognostic value of lipoprotein abnormalities in liver cirrhosis and to address the need of a better prognostic stratification of patients, including lipoprotein profile assessment. Low levels of lipoproteins are usual in cirrhosis. Much evidence supports the prognostic role of hypolipidemia in cirrhotic patients. In particular, hypocholesterolemia represents an independent predictor of survival in cirrhosis. In cirrhotic patients, lipoprotein impairment is associated with several complications: infections, malnutrition, adrenal function, and spur cell anemia. Alterations of liver function are associated with modifications of circulating lipids. Decreased levels of lipoproteins significantly impact the survival of cirrhotic patients and play an important role in the pathogenesis of some cirrhosis-related complications.

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Source
http://dx.doi.org/10.1007/s10620-017-4862-xDOI Listing

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