Molecular changes associated with neuronal aging lead to a decrease in cognitive capacity. Here we discuss these alterations at the level of brain regions, brain cells, and brain membrane and cytoskeletal proteins with an special focus in NMDA molecular changes through aging and its effect in cognitive decline and Alzheimer disease. Here, we propose that some neurodegenerative disorders, like Alzheimer's disease (AD), are characterized by an increase and acceleration of some of these changes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687061 | PMC |
| http://dx.doi.org/10.3389/fnins.2017.00626 | DOI Listing |
Publication Analysis
Top Keywords
cognitive decline
8
neuronal aging
8
alzheimer's disease
8
molecular changes
8
decline neuronal
4
aging alzheimer's
4
disease role
4
role nmda
4
nmda receptors
4
receptors associated
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!