Pre-organized polyaminopolycarboxylate chelators Cy-TTHA and Cy-DTPA were synthesized via modular five-step syntheses from commercially available starting materials in ~ 62% and 47% overall yields, respectively. Furthermore, strategies are reported for the efficient preparation of mono- and di-reactive, -butyl-protected TTHA/Cy-TTHA to selectively functionalize central chelators' carboxylic acids.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699510 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2017.02.056 | DOI Listing |
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