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Cell-free tumor DNA analysis in advanced or metastatic breast cancer patients: mutation frequencies, testing intention, and clinical impact.
Precis Clin Med
March 2025
Department of Gynecology and Obstetrics, CIO ABCD, University Hospital Düsseldorf, Düsseldorf 40225, Germany.
Background: Circulating cell-free tumor DNA (ctDNA) provides a non-invasive approach for assessing somatic alterations. The German PRAEGNANT registry study aims to explore molecular biomarkers and investigate their integration into clinical practice. In this context, ctDNA testing was included to understand the motivations of clinicians to initiate testing, to identify somatic alterations, and to assess the clinical impact of the results obtained.
View Article and Find Full Text PDFA rhodamine-conjugated fluorescent and colorimetric receptor for the detection of Cu ions: environmental utility and smartphone integration.
Anal Methods
January 2025
Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.
A new rhodamine based turn on florescent probe ()-3',6'-bis(ethylamino)-2-(((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methylene)amino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one (RME) was efficiently synthesized through a simple condensation reaction of 2-amino-3',6'-bis(ethylamino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one and 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde. The receptor RME is highly non-fluorescent and when copper ions (Cu ions) are added in DMF/water (1 : 2, v/v) medium, the receptor RME exhibits a specific "turn-on" colorimetric and fluorometric response. Moreover, RME binding with Cu ions produced a remarkable color variation that was perceptible to the human eye, changing from colorless to pink.
View Article and Find Full Text PDFPrognostic value of interim [F]FDG PET/CT after immunotherapy-based combinations in extranodal NK/T-cell lymphoma, nasal type.
Eur Radiol
January 2025
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Purpose: To evaluate the prognostic value of interim [F]Fluorodeoxyglucose positron emission tomography/computed tomography ([F]FDG PET/CT) after immunotherapy-based systemic therapies in extranodal natural killer/T-cell lymphoma (ENKTL).
Patients And Methods: We retrospectively recruited 133 newly diagnosed nasal-type ENKTL patients who underwent interim [F]FDG PET/CT scans after 2-4 cycles of immunotherapy-based treatments. Interim PET/CT was interpreted by maximum standardized uptake value (SUV), Deauville 5-point scale (DS), and early treatment response.
Metal-organic frameworks encapsulating gold nanoclusters and carbon dots for ratiometric fluorescent detection of formaldehyde in real food samples, construction materials and indoor environments.
Mikrochim Acta
January 2025
Hebei Lansheng Bio-Tech Co, Ltd, Shijiazhuang, 052263, P. R. China.
A novel fluorescence sensing nanoplatform (CDs/AuNCs@ZIF-8) encapsulating carbon dots (CDs) and gold nanoclusters (AuNCs) within a zeolitic imidazolate framework-8 (ZIF-8) was developed for ratiometric detection of formaldehyde (FA) in the medium of hydroxylamine hydrochloride (NHOH·HCl). The nanoplatform exhibited pink fluorescence due to the aggregation-induced emission (AIE) effect of AuNCs and the internal filtration effect (IFE) between AuNCs and CDs. Upon reaction between NHOH·HCl and FA, a Schiff base formed via aldehyde-diamine condensation, releasing hydrochloric acid.
View Article and Find Full Text PDFObjectives: To: 1) analyze possible differences in the CIEDE2000 lightness, chroma and hue of the gingiva at the free gingival margin (FGM) and the middle zone of keratinized gingiva (MZ) between participants with an ISFP in the maxillary anterior region and participants with natural dentition and healthy gums; and 2) examine the perceptibility/acceptability of the differences in CIEDE2000 lightness, chroma and hue and in overall color, using the Euclidean and CIEDE2000 formulae.
Methods: The L*, a* and b* color coordinates were measured in 60 adult participants (30 with an ISFP and 30 with healthy teeth and gums) using a Spectroshade™ Micro spectrophotometer. From these coordinates, the changes in lightness (ΔL'), chroma (ΔC') and hue (ΔH') CIEDE2000 between the participants with and without an ISFP were quantified.
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