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Virtual 3D reconstruction of complex congenital cardiac anatomy from 3D rotational angiography.
3D Print Med
January 2025
Department of Pediatric Cardiology, The Heart Institute, University of Colorado, Children's Hospital Colorado, 13123 E 16th Ave B100, 80045, Aurora, CO, USA.
Background: Despite advancements in imaging technologies, including CT scans and MRI, these modalities may still fail to capture intricate details of congenital heart defects accurately. Virtual 3D models have revolutionized the field of pediatric interventional cardiology by providing clinicians with tangible representations of complex anatomical structures. We examined the feasibility and accuracy of utilizing an automated, Artificial Intelligence (AI) driven, cloud-based platform for virtual 3D visualization of complex congenital heart disease obtained from 3D rotational angiography DICOM images.
View Article and Find Full Text PDFOperationalising a Haemophilia Gene Editing Lexicon for Practical Use.
Haemophilia
January 2025
Medicine and Pathology, Georgetown University, Washington, District of Columbia, USA.
Introduction: Gene editing therapies offer the possibility of substantial improvement in treatment and quality of life for people with haemophilia (PWH) in a landscape of dynamic therapeutic advancement. Developing a common and understandable language to discuss gene editing will be essential to ensure these treatments can be deployed in a safe and effective manner with fully informed and shared decision-making between healthcare professionals (HCPs) and PWH. A lexicon explaining and clarifying key concepts is one potential tool to address these aims.
View Article and Find Full Text PDFMHC Class II-Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy.
Allergy
January 2025
Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Background: IgE-mediated food allergy is accompanied by mucosal mast cell (MMC) hyperplasia in the intestinal mucosa. Intestinal MMC numbers correlate with the severity of food allergy symptoms. However, the mechanisms by which MMCs proliferate excessively are poorly understood.
View Article and Find Full Text PDFIncreasing trends of cannabinoid hyperemesis syndrome in youth: The grass is not always greener.
J Pediatr Gastroenterol Nutr
January 2025
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
This study investigated trends in suspected cannabinoid hyperemesis syndrome (CHS)-related emergency department visits among youth (15-24 years old) in the United States between 2006 and 2020. Using data from the Nationwide Emergency Room Sample, over 55,000 suspected CHS-related visits were identified, with an average annual increase of 28.1% per year.
View Article and Find Full Text PDFImpact of Hepatoblastoma on Infectious Complications Following Pediatric Liver Transplantation.
Pediatr Transplant
February 2025
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.
Background: Liver transplantation is the standard therapy for end-stage liver disease in pediatric patients with biliary atresia (BA), congenital and metabolic conditions, and for an unresectable malignant tumor like hepatoblastoma (HB). BA is the leading indication for pediatric liver transplantation, while HB is the most common childhood liver cancer. Despite improved outcomes through advanced surgical techniques and novel immunosuppression, pediatric liver transplantation (pLT) is complicated by post-transplant infections.
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