International studies have shown a significant reduction in colorectal cancer (CRC) mortality following the implementation of organized screening programs, given a sufficient participation rate and adequate follow-up. The French national CRC screening program has been generalized since 2008 and targets 18 million men and women aged 50-74 years. Despite broad recommendations, the participation rate remains low (29.8%), questioning the efficiency of the program. A panel of experts was appointed by the French National Cancer Institute to critically examine the place of autonomy and efficiency in CRC screening and propose recommendations. In this paper, we explore the ethical significance of a public health intervention that falls short of its objectives owing to low take-up by the population targeted. First, we analyze the reasons for the low CRC screening participation. Second, we examine the models that can be proposed for public health actions, reconciling respect for the individual and the collective good. Our expert panel explored possible ways to enhance take-up of CRC screening within the bounds of individual autonomy, adapting awareness campaigns, and new educational approaches that take into account knowledge and analysis of sociocultural hurdles. Although public health actions must be universal, target actions should nonetheless be developed for nonparticipating population subgroups.
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http://dx.doi.org/10.1097/CEJ.0000000000000417 | DOI Listing |
Background: Brain fluid flow plays a crucial role in maintaining brain health by eliminating potentially harmful waste products like amyloid-beta and tau [1-2]. This process is potentially facilitated by pulsations in the perivascular space, influenced by the neurovascular unit and autonomic nervous system, which may vary in brain diseases such as Alzheimer's disease (AD) [3-4]. Using a 7 Tesla MRI scanner and ultrafast echo-planar imaging (EPI), we developed a non-invasive neuroimaging methodology to characterize the in-vivo frequency and amplitude responses of pulsations of cerebrospinal fluid (CSF) flow.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, GIP Cyceron, Caen, France.
Background: Despite evidence that sex can modulate Alzheimer's disease (AD) risk, whether risk factors are similarly related to AD markers in women and men remains largely unexplored. We aimed to assess how a combination of potentially modifiable risk factors are associated with cognitive and pathological markers of AD in older women and men.
Method: We included 135 cognitively unimpaired older adults (≥65 years old, 83 women; Table 1) from the Age-Well trial (NCT02977819; baseline data) with multidomain assessments of modifiable risk factors, including cardiovascular (body mass index, systolic blood pressure, LDL cholesterol), lifestyle (complex mental activity throughout life, physical activity, diet), and psychological (quality of life, depressive and anxiety symptoms, rumination, worry).
Cancer Med
January 2025
Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
Background: Immune checkpoint inhibition therapies have provided remarkable results in numerous metastatic cancers, including mismatch repair-deficient (dMMR) colorectal cancer (CRC). To evaluate the potential for PD-1 blockade therapy in a large population-based cohort, we analyzed the tumor microenvironment and reviewed the clinical data and actualized treatment of all dMMR CRCs in Central Finland province between 2000 and 2015.
Material And Methods: Of 1343 CRC patients, 171 dMMR tumors were identified through immunohistochemical screening.
Alzheimers Dement
December 2024
GIGA-CRC, University of Liège, Liège, Liège, Belgium.
Background: Cognitive function alterations are a feature of the cognitive aging process. Additionally, aging is marked by macro- and micro-structural changes in the brain, such as gray matter (GM) atrophy, iron accumulation, and demyelination. This study explores the association between cognitive function and cooccurrence of brain micro- and macro-structural changes in healthy older adults.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Background: Despite evidence that sex can modulate Alzheimer's disease (AD) risk, whether risk factors are similarly related to AD markers in women and men remains largely unexplored. We aimed to assess how a combination of potentially modifiable risk factors are associated with cognitive and pathological markers of AD in older women and men.
Method: We included 135 cognitively unimpaired older adults ( = 65 years old, 83 women; Table 1) from the Age-Well trial (NCT02977819; baseline data) with multidomain assessments of modifiable risk factors, including cardiovascular (body mass index, systolic blood pressure, LDL cholesterol), lifestyle (complex mental activity throughout life, physical activity, diet), and psychological (quality of life, depressive and anxiety symptoms, rumination, worry).
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