AI Article Synopsis
- Some people can get Alzheimer's disease really early, often in their 30s or 40s, and it can run in families.
- Scientists found specific changes (mutations) in some genes that are linked to this early-onset Alzheimer's in two families from Iran.
- The disease gets worse quickly, with people usually living only a short time after they start showing symptoms.
Article Abstract
A subset of early-onset Alzheimer's disease is inherited as an autosomal-dominant trait and is associated with mutations in the genes encoding β-amyloid precursor protein, presenilin 1, or presenilin 2. In this study, we identified 2 PSEN1 mutations (1 novel and 1 known) in 2 unrelated Iranian families with autosomal-dominant Alzheimer's disease. The disease progressed rapidly with a mean age at onset of 33 and 42 years and an age at death ranging from 43 to 48 years.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743634 | PMC |
| http://dx.doi.org/10.1016/j.neurobiolaging.2017.10.011 | DOI Listing |
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