AI Article Synopsis
- Murraya koenigii is a plant in the Rutaceae family known for its medicinal benefits in Ayurveda, particularly for its antiviral, anti-inflammatory, and anticancer properties.
- Research has identified mahanine, a carbazole alkaloid, as the main active compound responsible for these effects, especially in cancer treatments.
- The review aims to compile data on the plant's cytotoxic constituents, the anticancer mechanisms of mahanine, and findings on its bioavailability and toxicity from recent studies.
Article Abstract
Murraya koenigii, a plant belonging to the Rutaceae family is widely distributed in Eastern-Asia and its medicinal properties are well documented in Ayurveda, the traditional Indian system of medicine. Through systematic research and pharmacological evaluation of different parts of the plant extracts has been shown to possess antiviral, anti-inflammatory, antioxidant, antidiabetic, antidiarrhoeal, antileishmanial, and antitumor activity. In the plant extracts, carbazole alkaloid, mahanine has been identified as the principle bioactive component among several other chemical constituents. Scientific evidence derived not only from in vitro cellular experiments but also from in vivo studies in various cancer models is accumulating for the pronounced anticancer effects of mahanine. The primary objective of this review is to summarize research data on cytotoxic chemical constituents present in different parts of Murraya koenigii and the anticancer activity of mahanine along with the recent understanding on the mechanism of its action in diverse cancer models. The information on its bioavailability and the toxicity generated from the recent studies have also been incorporated in the review.
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| http://dx.doi.org/10.1016/j.phrs.2017.11.024 | DOI Listing |
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