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A Risk Factor for Attention Deficit Hyperactivity Disorder Induces Marked Long-Term Anatomical Changes at GABAergic-Dopaminergic Synapses in the Rat Ventral Tegmental Area.
Int J Mol Sci
December 2024
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. However, the core biology of the disorder that leads to the hypofunctioning of the cerebral dopaminergic network requires further elucidation. We investigated midbrain synaptic changes in male rats exposed to repeated hypoxia during the equivalent of extreme prematurity, which is a new animal model of the hyperactive/impulsive presentation of ADHD.
View Article and Find Full Text PDFThe kinase LRRK2 is required for the physiological function and expression of the glial glutamate transporter EAAT2 (SLC1A2).
J Neurochem
January 2025
Department of Biotechnology and Life Sciences, Laboratory of Cellular and Molecular Physiology, University of Insubria, Varese, Italy.
Article Synopsis
- * EAAT2 dysfunction is linked to several neurodegenerative diseases, including Alzheimer's and Parkinson's, with specific mutations in LRRK2, particularly Gly2019Ser, reducing EAAT2 expression.
- * This study reveals that LRRK2 is essential for the stability and function of EAAT2, suggesting its role in preventing neuronal damage from excessive excitatory signals, but does not affect the function of other NTTs.
Geraniol Ameliorates Pentylenetetrazol-Induced Epilepsy, Neuroinflammation, and Oxidative Stress via Modulating the GABAergic Tract: In vitro and in vivo studies.
Drug Des Devel Ther
December 2024
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Alhofuf, Al-Ahsa, 31982, Saudi Arabia.
Introduction: Geraniol (Ger), a monoterpene, is a common constituent of several essential oils. This study explored the anticonvulsant effect of Ger in-vitro using nerve growth factor (NGF) prompted PC12 cell injured by Glutamate (Glu) and in-vivo using Pentylenetetrazole (PTZ)-induced kindling through the GABAergic pathway.
Materials: To assess the effect of Ger on NGF prompted PC12 cells injured by Glu, Ger at concentrations of 25, 50, 100, 200 and 400 μg/mL was used.
Essential tremor - drug treatments present and future.
Expert Rev Neurother
December 2024
Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain.
Introduction: The main treatment options for essential tremor (ET), which is probably one of the most common movement disorders, have been propranolol and primidone, for many years. This review aims to synthesize therapeutic attempts with other drugs.
Areas Covered: We have reviewed the current state of the pharmacological treatment of ET, both in patients and in experimental models of this disease, with special emphasis on the data published in the last 5 years.
Systematic Review of Experimental Deep Brain Stimulation in Rodent Models of Epilepsy.
Neuromodulation
December 2024
Neurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:
Objectives: Deep brain stimulation (DBS) is an established neuromodulatory technique for treating drug-resistant epilepsy. Despite its widespread use in carefully selected patients, the mechanisms underlying the antiseizure effects of DBS remain unclear. Herein, we provide a detailed overview of the current literature pertaining to experimental DBS in rodent models of epilepsy and identify relevant trends in this field.
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