AI Article Synopsis
- The study aimed to compare methylation patterns in white blood cells of preterm and full-term newborns to identify differences.
- Researchers analyzed 24 preterm and 22 full-term infants at 12 months post-gestation, evaluating various health indicators and developmental milestones at 24-36 months.
- Results indicated significant differences in methylation levels of the SLC6A3 gene, linked to prematurity and associated with neurodevelopmental issues, suggesting it could serve as an early biomarker for diagnosing related disorders.
Article Abstract
Aim: To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells.
Patients & Methods: Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (Spain) were assessed at 12 months of gestational age, whereas Bayley Scale of Infant Development was evaluated at 24/36 months.
Results: From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors.
Conclusion: SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmental diseases in newborns.
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| http://dx.doi.org/10.2217/epi-2017-0082 | DOI Listing |
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