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Immune-related tumour response assessment criteria: a comprehensive review. | LitMetric

AI Article Synopsis

  • The rise of precision medicine in oncology is driving the use of targeted therapies, particularly immune therapeutic drugs, which differ from traditional cancer treatments.
  • These immune therapies can lead to unique imaging responses such as delayed changes, transient tumor enlargement, or the appearance of new lesions, complicating the monitoring of treatment effectiveness.
  • Traditional evaluation criteria like WHO standards are becoming inadequate, prompting the development of new criteria tailored to immune therapies, which are increasingly being used in clinical trials to better assess patients.

Article Abstract

Growing emphasis on precision medicine in oncology has led to increasing use of targeted therapies that encompass a spectrum of drug classes including angiogenesis inhibitors, immune modulators, signal transduction inhibitors, DNA damage modulators, hormonal agents etc. Immune therapeutic drugs constitute a unique group among the novel therapeutic agents that are transforming cancer treatment, and their use is rising. The imaging manifestations in patients on immune therapies appear to be distinct from those typically seen with conventional cytotoxic therapies. Patients on immune therapies may demonstrate a delayed response, transient tumour enlargement followed by shrinkage, stable size, or initial appearance of new lesions followed by stability or response. These newer patterns of response to treatment have rendered conventional criteria such as World Health Organization and response evaluation criteria in solid tumours suboptimal in monitoring changes in tumour burden. As a consequence, newer imaging response criteria such as immune-related response evaluation criteria in solid tumours and immune-related response criteria are being implemented in many trials to effectively monitor patients on immune therapies. In this review, we discuss the traditional and new imaging response criteria for evaluation of solid tumours, review the outcomes of various articles which compared traditional criteria with the new immune-related criteria and discuss pseudo-progression and immune-related adverse events.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966001PMC
http://dx.doi.org/10.1259/bjr.20170457DOI Listing

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