Aim: To compare the measurement of total body water (TBW) and fat-free mass (FFM) using the criterion method of deuterium dilution space (HO) with bioelectrical impedance analysis (BIA) using a portable QuadScan 4000, Bodystat in children and adolescents with phenylketonuria (PKU).
Methods: Sixteen patients with PKU, median age is 12.5 (range 5-20.6) years, were recruited into this cross-sectional study. TBW was measured by both deuterium dilution and BIA on the same occasion as per a standard protocol. FFM was estimated from predictive equations.
Results: There was no significant difference between TBW and TBW (p = 0.344) or FFM and FFM (p = 0.111). TBW and TBW were highly correlated (r = 0.990, p < 0.0001), as were FFM and FFM (r = 0.984, p < 0.0001). Bland-Altman plots demonstrated that there was no proportional bias between the criterion method, TBW, and the test method TBW, in estimating TBW (β = -0.056, adjusted r = 0.069, p = 0.169) or FFM (β = -0.089, adjusted r = 0.142, p = 0.083).
Conclusion: Our results suggest that when compared with the criterion method, the QuadScan 4000, Bodystat can reliably be used to predict TBW and FFM in patients with PKU. We suggest that due to the portability and non-invasive approach, this method can reliably be used to monitor body composition in the outpatient clinic setting, to further improve the monitoring and assessment of nutritional status in PKU.
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| http://dx.doi.org/10.1007/8904_2017_75 | DOI Listing |
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