AI Article Synopsis
- Microsurgical techniques and peritoneal conditioning during laparoscopic surgery (LS) help reduce postoperative adhesions and pain, but there's a need to confirm the benefits of nitric oxide (NO) in open surgery (OS).
- A study using a mouse model showed that the type and duration of gas exposure significantly impact adhesion formation and can affect mortality rates during OS.
- Results highlighted that low concentrations of NO effectively reduce adhesions in OS, confirming its strong beneficial effects observed in LS.
Article Abstract
Background: Microsurgical tenets and peritoneal conditioning during laparoscopic surgery (LS) decrease postoperative adhesions and pain. For a trial in human, the strong beneficial effects of NO needed to be confirmed in open surgery (OS).
Results: In a mouse model for OS, the effect of the gas environment upon adhesions was evaluated. Experiment I evaluated desiccation and the duration of exposure to CO, NO or CO + 4%O. Experiment II evaluated the dose-response curve of adding NO to CO. Experiment III compared humidified CO + 10% NO during LS and OS.In OS, 30- and 60-min exposure to non-humidified CO caused mortality of 33 and 100%, respectively. Mortality was prevented by humidification, by dry NO or dry CO + 4%O. Adhesions increased with the duration of exposure to CO ( < 0.0001) and decreased slightly by humidification or by the addition of 4% O. NO strongly decreased adhesions at concentrations of 5% or greater. With humidified CO + 10% NO, adhesion formation was similar in OS and LS.
Conclusions: The drug-like and strong beneficial effect of low concentrations of NO is confirmed in OS.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676824 | PMC |
| http://dx.doi.org/10.1186/s10397-017-1024-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!