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Background: Glycosylated hemoglobin (HbA1c) is a stable compound in human blood that covalently binds the N-terminal valine residue of the β-chain in hemoglobin A to the free aldehyde group of glucose. It can reflect the average blood glucose level of patients in the past 2 - 3 months. Therefore, the accuracy of HbA1c detection results is of great significance for the diagnosis and differential diagnosis of diabetes.
View Article and Find Full Text PDFReassessing very long chain fatty acids elevations: Sitosterolemia as a non-peroxisomal cause.
Mol Genet Metab Rep
March 2025
Demiroglu Bilim University Faculty of Medicine, Department of Medical Genetics, Istanbul, Türkiye.
Very-long-chain fatty acids (VLCFAs) are commonly used to diagnose peroxisomal disorders, but elevated levels may also result from other non-peroxisomal causes, leading to diagnostic challenges. We report the case of a 2-year-old girl presenting with growth retardation and diarrhea, with laboratory investigations revealing elevated VLCFA levels suggestive of a peroxisomal disorder. Despite initial suspicion, genetic panels for peroxisomal and dyslipidemia-associated genes were negative.
View Article and Find Full Text PDFα-Acid Glycoprotein with Highly Fucosylated Glycans as a Potential Diagnostic Marker for Early Detection of Hepatobiliary and Pancreatic Cancers.
Diagnostics (Basel)
December 2024
Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
: Previously, we reported elevated levels of fucosylated α-acid glycoprotein (fAGP) in plasma samples from patients with diverse types of cancers. Accordingly, fAGP was assumed to be a potential biomarker for the early detection of cancers. : The fAGP level was retrospectively measured in preoperative plasma samples from 213 patients with either hepatic, biliary tract, or pancreatic cancer and was analyzed together with levels of six existing tumor markers determined as reference standards.
View Article and Find Full Text PDFElevation of erythrocyte creatine post-puberty unrelated to erythrocyte lifespan: Implications from the lack of correlation between HbA1c and erythrocyte creatine.
Clin Chim Acta
January 2025
Department of Internal Medicine, Hakuhokai Central Hospital, 4-23-1 Higahisonodacho, Amagasaki 661-0953, Japan. Electronic address:
Article Synopsis
- The study examined how erythrocyte creatine (EC) and HbA1c levels relate in healthy children aged 3-18 years, finding no significant correlation between the two measures.
- In males, while EC levels did not correlate with age, they showed a negative trend with HbA1c; in females, EC levels positively correlated with age but not with HbA1c.
- Notably, menstruating females had higher EC levels compared to non-menstruating ones, yet there were no significant differences in HbA1c levels, suggesting a potential age-related discrepancy in females after puberty.
Endovascular laser fenestration of a frozen elephant trunk stent graft for treatment of chronic cerebral malperfusion.
Vascular
January 2025
Division of Vascular Surgery, Medical University of South Carolina, Charleston, SC, USA.
Objectives: Mal-deployment of the thoracic endovascular aortic repair (TEVAR) stent graft during a frozen elephant trunk (FET) procedure for an acute type A aortic dissection (ATAAD) leads to devastating complications. We report a hemiarch replacement with TEVAR stent graft covering the aortic arch vessels salvaged through an endovascular approach.
Methods: A 69-year-old man with ATAAD in 2018, status post-hemiarch repair with TEVAR, presented in 2023 with progressive dizziness/syncope and lower extremity hypertension with inability to tolerate anti-hypertensives.
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