AI Article Synopsis
- A recent study explored the association of a genetic marker (rs12204590) near chromosome 6p25 with ischemic stroke risk in a Chinese Han population, finding no significant link to stroke incidence.
- A novel SNP (rs1711972) was identified that may increase the risk of large-artery atherosclerotic stroke, showing a modest association in subgroup analyses.
- The findings suggest that while rs12204590 does not correlate with ischemic stroke in this population, rs1711972 could play a role in large-artery atherosclerotic stroke risk among Chinese Han individuals.
Article Abstract
Recently, a novel locus at chromosome 6p25 (rs12204590, near ) associated with an increased risk of stroke in European populations was identified. However, whether polymorphisms in are also associated with the incidence of ischemic stroke in other populations remains unknown. In this case-control study, 803 Chinese Han patients with ischemic stroke and 803 matched control individuals were enrolled. Four tag SNPs and rs12204590 located in or near were selected, and the associations between genotypes/alleles and ischemic stroke were analyzed. In our study, we did not detect an association between the previously reported locus rs12204590 and ischemic stroke. By the genotype analysis, a novel SNP rs1711972, near , was observed to be associated with an increased risk of ischemic stroke(CA genotype, adjusted OR = 1.35; 95% CI, 1.07 to 1.70), but not significantly after Bonferroni corrections for multiple tests. However, in the subgroup analysis, we discovered that rs1711972 was associated with an increased risk of large-artery atherosclerotic stroke in the additive model ( = 0.020; CA genotype, adjusted OR = 1.50; 95%CI, 1.09 to 2.07) and dominant model ( = 0.010; OR = 1.47; 95%CI, 1.09 to 1.99). Collectively, these results indicate that a novel SNP near may influence the risk of large-artery atherosclerotic stroke in Chinese Han population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685715 | PMC |
| http://dx.doi.org/10.18632/oncotarget.21263 | DOI Listing |
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