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Predicting Surgical Outcome in Patients With Drug-Resistant Epilepsy Using Autoregressive Connectivity and Virtual Resection.
IEEE J Biomed Health Inform
March 2025
Epilepsy is a brain network disorder that manifests through recurrent seizures. In cases of drug-resistant epilepsy, surgical removal of pivotal nodes within the epileptic brain network can lead to seizure freedom. Virtual resection on patient-specific brain network models can aid in the prediction of surgical outcomes.
View Article and Find Full Text PDFParental autonomy and children's health: a patriarchal dilemma in the Middle East, with particular emphasis on Kuwait.
Med Law Rev
January 2025
School of Law, Kuwait University, Kuwait City, Safat 12037, Kuwait.
In 2020, Kuwaiti mothers won legal medical guardianship over their children, enabling them to authorize medical treatment, this despite still not having autonomy for their own medical care, yet being vicariously liable for potential tort caused by their child. This dichotomy raises questions over the implementation of the new legislation, if the mother and the male guardian had opposing views over the child's health. Recent years have seen the UK cases of Charlie Gard and Alfie Evans initiate passionate ethical debate when courts invoked Parens Patriae, superseding parental autonomy and supporting clinicians' decisions to withdraw life support.
View Article and Find Full Text PDFTotal lesion glycolysis of primary tumor and lymphnodes is a strong predictor for development of distant metastases in oropharyngeal carcinoma patients with independent validation in automatically delineated lesions.
Cancer Imaging
February 2025
Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Background: Oropharyngeal carcinomas are characterized by an increasing incidence and a relatively good prognosis. Nonetheless, a considerable number of patients develops metachronous distant metastases; identification of these patients is an urgent medical need.
Methods: This is a retrospective multicenter evaluation of 431 patients.
Setting higher standards for migraine prevention: A position statement of the International Headache Society.
Cephalalgia
February 2025
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Migraine is one of the most prevalent and disabling neurological diseases, significantly affecting quality of life and productivity, as well as contributing to substantial societal costs. Recent innovations, including calcitonin gene-related peptide (CGRP) pathway inhibitors and onabotulinumtoxinA, have transformed migraine prevention by offering high efficacy and excellent tolerability, thus improving adherence. Clinical trials and real-world studies show that significant reductions in migraine frequency and, in some cases, complete migraine freedom is achievable.
View Article and Find Full Text PDFRestriction of Posterior Tibial Translation During the Posterior Drawer Test in Internal or External Rotation Is Dependent on Peripheral Stabilizers of the Knee: A Biomechanical Robotic Investigation.
Am J Sports Med
February 2025
Department of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany.
Background: The posteromedial and posterolateral structures of the knee have previously been shown to be secondary restraints to posterior tibial translation (PTT). The effect of these structures may increase when performing the posterior drawer test in internal or external rotation.
Purpose/hypothesis: The purpose was to investigate the influence of the posteromedial and posterolateral structures on restricting PTT in neutral, external, and internal rotation.
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