Preferences and behavior are heavily influenced by one's current visceral experience, yet people often fail to anticipate such effects. Although research suggests that this gap is difficult to overcome-to act as if in another visceral state-research on mental simulation has demonstrated that simulations can substitute for experiences, albeit to a weaker extent. We examine whether mentally simulating visceral states can impact preferences and behavior. We show that simulating a specific visceral state (e.g., being cold or hungry) shifts people's preferences for relevant activities (Studies 1a-2) and choices of food portion sizes (Study 3). Like actual visceral experiences, mental simulation only affects people's current preferences but not their general preferences (Study 4). Finally, people project simulated states onto similar others, as is the case for actual visceral experiences (Study 5). Thus, mental simulation may help people anticipate their own and others' future preferences, thereby improving their decision making.
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http://dx.doi.org/10.1177/0146167217741315 | DOI Listing |
Cell
December 2024
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA; Chan Zuckerberg Biohub, San Francisco, CA 94148, USA; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94115, USA. Electronic address:
Three proton-sensing G protein-coupled receptors (GPCRs)-GPR4, GPR65, and GPR68-respond to extracellular pH to regulate diverse physiology. How protons activate these receptors is poorly understood. We determined cryogenic-electron microscopy (cryo-EM) structures of each receptor to understand the spatial arrangement of proton-sensing residues.
View Article and Find Full Text PDFJ Neurosurg
January 2025
1Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Objective: Deep brain stimulation (DBS) is an effective neurosurgical option for patients with treatment-resistant obsessive-compulsive disorder (OCD). Despite being more costly than neuroablative procedures of comparable efficacy, DBS has gained popularity over the years for its reversibility and adjustability. Although the cost-effectiveness of DBS has been investigated extensively in movement disorders, few economic analyses of DBS for psychiatric disorders exist.
View Article and Find Full Text PDFBackground: Cognitive dysfunction is central to clinicopathological models of Alzheimer's disease (AD). While AD prospective studies assess similar cognitive domains, the neuropsychological tests used vary between studies, limiting potential for aggregation. We examined a machine learning (ML) data harmonisation method for neuropsychological test data to develop a harmonised PACC score for the Alzheimer's Dementia Onset and Progression in International Cohorts (ADOPIC) consortium.
View Article and Find Full Text PDFBackground: Predicting decline over the course of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), especially on relatively short time frames, is vital for appropriate treatment planning and to tailor patient and support systems' expectations. The current study tested if a functional upper limb motor learning task could predict one-year change in cognition and daily function.
Method: Cognitively unimpaired (n = 61), MCI (n = 35), and AD (32) older subjects (age: 74.
Radiol Imaging Cancer
January 2025
From the Department of Clinical Affairs, MediView XR, Cleveland, Ohio (M.E.); College of Medicine, Alfaisal University, Riyadh, Saudi Arabia (A.B.); and Department of Diagnostic Radiology, Section of Interventional Radiology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195-5243 (S.K., K.G., C.M.).
Percutaneous tumor ablation has become a widely accepted and used treatment option for both soft and hard tissue malignancies. The current standard-of-care techniques for performing these minimally invasive procedures require providers to navigate a needle to their intended target using two-dimensional (2D) US or CT to obtain complete local response. These traditional image-guidance systems require operators to mentally transpose what is visualized on a 2D screen into the inherent three-dimensional (3D) context of human anatomy.
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