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The role of the KEAP1-NRF2 signaling pathway in form deprivation myopia guinea pigs.
BMC Ophthalmol
November 2024
Ophthalmology Department of Affiliated Hospital of North Sichuan Medical College, Medical School of Ophthalmology & Optometry, Nanchong, Sichuan Province, 637000, China.
Article Synopsis
- Myopia rates have surged globally, particularly in East Asia, and research indicates its complex causes, including a potential link to oxidative stress (OS).
- The study examined the KEAP1-NRF2 signaling pathway and its role in myopia development in form-deprivation myopia guinea pigs, revealing the effect of tert-butylhydroquinone (TBHQ) treatment on slowing myopia progression.
- Results indicated that TBHQ activates NRF2, promotes KEAP1 degradation, and boosts superoxide dismutase (SOD) levels, enhancing the retinal antioxidant capacity and potentially influencing myopia development.
Real-Time Visualization of Infiltration and Retention of Microplastics with Different Shapes in Porous Media.
Environ Sci Technol
November 2024
Key Laboratory of Coastal Environment and Resources of Zhejiang Province, School of Engineering, Westlake University, Hangzhou 310024, China.
Infiltration and retention of microplastics in porous media are important for understanding their fate in environments and formulating treatment measures. Given porous media opacity, knowledge is usually obtained indirectly by monitoring microplastic concentration in the effluent and measuring microplastic distribution after removing grains in layers. In this study, real-time visualization of infiltration and retention of microplastics in porous media under vertical water flow is performed using an improved reflective index matching method, considering the different shapes and densities of microplastics and size ratios between microplastics and grains.
View Article and Find Full Text PDFEffect of alginate coating activated by solid lipid nanoparticles containing Zataria multiflora essential oil on chicken fillet's preservation.
Food Chem
July 2024
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:
The current study aimed to assess the chemical, microbial, and sensory properties of Solid Lipid Nanoparticles (SLNs) in chicken fillets stored at 4 ± 1 °C for 12 days. As a result, the optimized ZEO-SLNS sample exhibited a spherical morphology with a droplet size of 251.51 ± 1.
View Article and Find Full Text PDFIdentifying and Exploring the Impact Factors for Intraocular Pressure Prediction in Myopic Children with Atropine Control Utilizing Multivariate Adaptive Regression Splines.
J Pers Med
January 2024
Graduate Institute of Business Administration, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Purpose: The treatment of childhood myopia often involves the use of topical atropine, which has been demonstrated to be effective in decelerating the progression of myopia. It is crucial to monitor intraocular pressure (IOP) to ensure the safety of topical atropine. This study aims to identify the optimal machine learning IOP-monitoring module and establish a precise baseline IOP as a clinical safety reference for atropine medication.
View Article and Find Full Text PDFGoethite adaptation prompts alterations in antibiotic susceptibility and suppresses development of antibiotic resistance in bacteria.
Sci Total Environ
March 2024
Institute of Environmental Research at Great Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, Guangdong 510006, PR China.
Understanding the impact of environmental factors on antibiotic sensitivity and the emergence of antibiotic resistance in microorganism is crucial for antibiotics management and environmental risk assessment. Natural materials, like mineral particles, are prevalent in aquatic and terrestrial ecosystems. However, it remains unclear how microorganism adapt to the physical stress of mineral particles and whether this adaptation influences antibiotic sensitivity and the evolution of antibiotic resistance.
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