AI Article Synopsis
- - The FrzCD chemoreceptor in Myxococcus xanthus creates central clusters within the cell body, co-locating with its genetic material (nucleoid).
- - FrzCD binds to the nucleoid through its positively charged tail, which helps recruit signaling complexes, acting independently of specific DNA sequences.
- - The clustering of FrzCD may enable cooperative interactions among receptors, similar to how membrane-bound chemosensory arrays function.
Article Abstract
The FrzCD chemoreceptor from the gliding bacterium Myxococcus xanthus forms cytoplasmic clusters that occupy a large central region of the cell body also occupied by the nucleoid. In this work, we show that FrzCD directly binds to the nucleoid with its N-terminal positively charged tail and recruits active signaling complexes at this location. The FrzCD binding to the nucleoid occur in a DNA-sequence independent manner and leads to the formation of multiple distributed clusters that explore constrained areas. This organization might be required for cooperative interactions between clustered receptors as observed in membrane-bound chemosensory arrays.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716589 | PMC |
| http://dx.doi.org/10.1371/journal.pgen.1007103 | DOI Listing |
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