AI Article Synopsis
- MicroRNAs (miRNAs) are short single-stranded RNAs (18-25 nucleotides) that play a key role in regulating gene expression after transcription.
- They are involved in various biological processes, including cell growth, programmed cell death, development, and the development of cancer.
- The regulation of miRNA expression is crucial and can be influenced by epigenetic mechanisms, particularly through DNA methylation and modifications to histones.
Article Abstract
MicroRNAs (miRNAs) are single-stranded RNAs of 18-25 nucleotides that regulate gene expression at the post-transcriptional level. They are involved in many physiological and pathological processes, including cell proliferation, apoptosis, development and carcinogenesis. Because of the central role of miRNAs in the regulation of gene expression, their expression needs to be tightly controlled. Here, we summarize the different mechanisms of epigenetic regulation of miRNAs, with a particular focus on DNA methylation and histone modification.
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| http://dx.doi.org/10.1515/bmc-2017-0024 | DOI Listing |
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