Correction for 'Direct N-H/α,α,β,β-C(sp)-H functionalization of piperidine via an azomethine ylide route: synthesis of spirooxindoles bearing 3-substituted oxindoles' by Yanlong Du et al., Chem. Commun., 2017, 53, 1684-1687.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7cc90452eDOI Listing

Publication Analysis

Top Keywords

n-h/ααββ-csp-h functionalization
8
functionalization piperidine
8
piperidine azomethine
8
azomethine ylide
8
ylide route
8
route synthesis
8
synthesis spirooxindoles
8
spirooxindoles bearing
8
bearing 3-substituted
8
correction direct
4

Similar Publications

Polyunsaturated fatty acids (PUFAs) including omega-3 and omega-6 are obtained from diet and can be measured objectively in plasma or red blood cells (RBCs) membrane biomarkers, representing different dietary exposure windows. In vivo conversion of omega-3 and omega-6 PUFAs from short- to long-chain counterparts occurs via a shared metabolic pathway involving fatty acid desaturases and elongase. This analysis leveraged genome-wide association study (GWAS) summary statistics for RBC and plasma PUFAs, along with expression quantitative trait loci (eQTL) to estimate tissue-specific genetically predicted gene expression effects for delta-5 desaturase (FADS1), delta-6 desaturase (FADS2), and elongase (ELOVL2) on changes in RBC and plasma biomarkers.

View Article and Find Full Text PDF

A divergent two-domain structure of the anti-Müllerian hormone prodomain.

Proc Natl Acad Sci U S A

January 2025

Department of Molecular & Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45267.

TGFβ family ligands are synthesized as precursors consisting of an N-terminal prodomain and C-terminal growth factor (GF) signaling domain. After proteolytic processing, the prodomain typically remains noncovalently associated with the GF, sometimes forming a high-affinity latent procomplex that requires activation. For the TGFβ family ligand anti-Müllerian hormone (AMH), the prodomain maintains a high-affinity interaction with its GF that does not render it latent.

View Article and Find Full Text PDF

Drug Property Optimization: Design, Synthesis, and Characterization of Novel Pharmaceutical Salts and Cocrystal-Salt of Lumefantrine.

Mol Pharm

January 2025

Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.

Lumefantrine (LMF) is a low-solubility antimalarial drug that cures acute, uncomplicated malaria. It exerts its pharmacological effects against erythrocytic stages of spp. and prevents malaria pathogens from producing nucleic acid and protein, thereby eliminating the parasites.

View Article and Find Full Text PDF

The initial decomposition reactions of 1,3,5-trinitrobenzene (TNB), picric acid (PA), 2,4,6-trinitrotoluene (TNT), 2,4,6-trinitroaniline (TNA) and 2,4,6-trinitrophenylmethylnitramine (Tetryl) were studied using ReaxFF-lg molecular dynamics simulations, and the substituent effect on the thermal decomposition behaviours of nitrobenzene compounds was evaluated through the reactant number, initial decomposition pathway, products and cluster analysis. The results show that the introduction of substituents could promote the decomposition of the reactants, increase the frequency of the nitro-nitrito isomerization reaction and intermolecular H or O atom transfer reaction, and reduce the frequency of the direct nitro dissociation reaction. Notably, these effects were most obvious in the case of TNT.

View Article and Find Full Text PDF

Magnesium-containing molecules, including MgCH, MgCH, and MgCH, have been detected in the interstellar medium, largely facilitated by their high dipole moments. However, despite great efforts, MgCH species remain elusive. Given the challenges in obtaining experimental data for these molecules, theoretical studies play a crucial role in guiding their detection.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!