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| http://dx.doi.org/10.1016/j.jdcr.2017.09.027 | DOI Listing |
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Repigmentation in non-segmental vitiligo using the Janus kinase inhibitor upadacitinib, a retrospective case series.
Arch Dermatol Res
December 2024
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.12 Jiangwangmiao, Xuanwu District, Nanjing, 210042, Jiangsu, China.
Vitiligo is the most frequently diagnosed depigmentation disease, affecting nearly 0.5-2% of individuals worldwide. This disorder is characterized by melanocyte loss, which results in skin and hair depigmentation.
View Article and Find Full Text PDFPotential execution of vitiligo surgery by the most conceivable technique - which, where, and why?
J Cutan Aesthet Surg
October 2024
Department of Dermatology, The Humanitarian Clinic: Skin, Hair and Laser Centre, Mumbai, Maharashtra, India.
While various treatment options exist for vitiligo, surgical interventions have gained significant attention due to their potential for long-lasting repigmentation. Several surgical procedures have been developed, including miniature punch grafting, thin Theirsch's split-thickness skin grafting (STSG), suction blister technique, and ultrathin STSG. The decision-making process should also consider the potential risks and benefits associated with each technique.
View Article and Find Full Text PDFJAK inhibitors in immune regulation and treatment of vitiligo.
Cytokine Growth Factor Rev
December 2024
Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China; Department of Dermatology, The First Hospital of China Medical University, Shenyang, China. Electronic address:
Article Synopsis
- - Vitiligo is a skin disorder characterized by loss of pigmentation, affecting both the appearance and mental well-being of those affected, as it involves a decrease in functioning melanocytes which produce skin color.
- - Treatment options for vitiligo include glucocorticoids, immunosuppressants, phototherapy, and surgical methods, but recent studies highlight the role of Janus kinase (JAK) hyperactivation and pro-inflammatory cytokines in escalating the condition by harming melanocytes.
- - New research shows that JAK inhibitors can effectively counteract the negative effects of these signaling pathways, leading to potential repigmentation of the skin, and this review discusses their mechanisms and applications for improving vitiligo treatments.
Topical 5-aminolevulinic acid photodynamic therapy for genital vitiligo.
Photodiagnosis Photodyn Ther
December 2024
Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan 430022, Hubei, PR China. Electronic address:
Vitiligo is an acquired chronic depigmentary skin disorder which results from the destruction of melanocytes. The clinical characteristic of vitiligo is the development of white macules due to the loss of functioning melanocytes in the skin or hair. Vitiligo in the genital area brings about a serious psychological impact on individuals.
View Article and Find Full Text PDFA Systematic Review of Case Series and Clinical Trials Investigating Regenerative Medicine for the Treatment of Vitiligo.
J Cosmet Dermatol
November 2024
Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Aims And Objectives: The aim of this study is to examine the efficacy and safety of various regenerative medicine treatments, such as cell therapy, platelet-rich plasma (PRP), plasma-poor platelet (PPP), plasma-rich fibrin (PRF), mesenchymal stem cells, stromal vascular fraction (SVF), exosomes, adipose-derived stem cells (ADSC), and stem cell-conditioned media (SC-CM), for treating vitiligo.
Method: We conducted a thorough search of major databases such as PubMed, Scopus, and Web of Science, and selected 48 articles based on specific criteria. We used EndNote X8 and Google Sheets to review and extract data from the articles.
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