AI Article Synopsis
- Septo-optic dysplasia (SOD) is a rare condition marked by underdeveloped optic nerves, pituitary issues, and defects in certain brain structures, which can sometimes lead to drug-resistant epilepsy.
- This report examines six SOD patients who also faced malformations of cortical development (MCD) and had drug-resistant epilepsy, documented during video-EEG telemetry from 1998 to 2016.
- Out of these patients, three underwent surgical procedures including neocortical resection, functional hemispherectomy, and vagus nerve stimulation to address their epilepsy, with discussions on their clinical outcomes.
Article Abstract
Septo-optic dysplasia (SOD) is a rare disorder associated with optic nerve hypoplasia, pituitary abnormalities and agenesis/dysgenesis of midline brain structures including the septum pellucidum and corpus callosum. Though sometimes associated with drug-resistant epilepsy, this association has not been well studied. We report six SOD patients with associated malformation of cortical development (MCD) and drug-resistant epilepsy who underwent video-EEG telemetry at our centre between 1998 and 2016 for drug-resistant epilepsy. Three then underwent surgery; right temporal neocortical resection, right functional hemispherectomy and placement of a vagus nerve stimulator. Clinical findings and the patients' ultimate courses are discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678750 | PMC |
| http://dx.doi.org/10.1016/j.ebcr.2017.04.001 | DOI Listing |
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