Frailty and the Quality of Life in Hemodialysis Patients: The Importance of Waist Circumference.

Objective: Frailty among the end-stage renal disease (ESRD) population is highly prevalent and has been associated with mortality. Little is known about the relation of different aspects of body composition, a modifiable risk factor, with the risk of frailty in ESRD population.

Design And Methods: One hundred and fifty-one patients including 85 men and 66 women, aged ≥18 years with ESRD who had been receiving conventional maintenance hemodialysis (HD) for at least 3 months were included. Body fat and muscle mass from both bioimpedance spectroscopy and skin-fold thickness and waist circumference as a surrogate of abdominal obesity were measured. Frailty was defined based on Fried's criteria. Health-related quality of life was collected using the RAND version of the Kidney Disease Quality of Life (KDQOL-36) Survey.

Results: We performed single and multiple predictor logistic regression analyses to determine factors associated with frailty. After adjustment for age, sex, and comorbidities, fat mass (both by bioimpedance spectroscopy and anthropometry) and waist circumference, but not muscle mass remained the main predictors of frailty. The odds ratio of frailty in the third tertile compared with the first was 4.97 (1.70-14.55) and 3.84 (1.39-10.61) for fat mass and waist circumference, respectively (P for trends for both <.05). The scores of physical health and kidney disease effect component of quality of life were lower in frail compared with nonfrail patients (40.7 ± 9.2 vs. 33.7 ± 10.2, P < .01 and 66.8 ± 22.4 vs. 51.6 ± 25.7, P < .05 for physical health and effects of disease, respectively).

Conclusions: Frailty, which is associated with poor outcomes in chronic HD patients, is common and predicted by fat mass and waist circumference but not by body mass index and muscle mass. Interventions to modify abdominal obesity, reflected by waist circumference, could potentially lower the incidence of frailty and hence improve the quality of life in the HD population.