AI Article Synopsis
- Circular RNAs (circRNAs) are important non-coding RNAs linked to various diseases, especially cancers, but their roles in cervical cancer are not well understood.
- Recent studies identified 45 circRNAs significantly expressed in cervical cancer tissues, with hsa_circ_0018289 showing a notable increase in expression compared to normal tissues.
- Further experiments revealed that hsa_circ_0018289 contributes to cervical cancer cell growth and spread by acting as a "sponge" for miR-497, highlighting its potential role in promoting tumor development.
Article Abstract
Circular RNAs (circRNAs) are a type of non-coding RNAs that have been identified as critical regulators in various diseases, especially in cancers. However, the expression profiles and functions of circRNAs in cervical cancer are still unclear. In present study, human circRNAs microarray were performed to screen the circRNAs expression in cervical cancer tissue. Microarray analysis revealed 45 significantly expressed circRNAs with 4 fold change. Among these up-regulated circRNAs, hsa_circ_0018289 was validated to be significantly up-regulated in 35 pairs of cervical cancer tissue compared with adjacent normal tissue and cell lines. Loss-of-function experiments revealed that, and , hsa_circ_0018289 knockdown inhibited the proliferation, migration and invasion of cervical cancer cells. Via bioinformatics prediction program and luciferase reporter assays, hsa_circ_0018289 was observed to directly bind to miR-497. Taken together, the results indicate that hsa_circ_0018289 plays important role in cervical cancer proliferation, migration and invasion, suggesting the miRNA 'sponge' of hsa_circ_0018289 and its oncogenic role on cervical cancer tumorigenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689712 | PMC |
| http://dx.doi.org/10.18632/oncotarget.21257 | DOI Listing |
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