AI Article Synopsis
- Response inhibition is linked to monoamine-related gene polymorphisms, but the relationship remains unclear, prompting a systematic review of related studies.
- Thirty-eight studies were identified, focusing on over 15 candidate genes, yet no definitive conclusions about their effects on response inhibition could be made.
- Meta-analyses of three specific polymorphisms showed no consistent association with response inhibition performance, leading to discussions on the implications of these findings and suggestions for future research.
Article Abstract
Response inhibition has been shown to be associated with monoamine-related gene polymorphisms, although evidence is inconclusive. To comprehensively examine these genotype effects on behavioural correlates of response inhibition in non-clinical adult populations, we performed a two-step approach. A systematic review of studies using Go/No-Go and/or Stop-Signal paradigms was first carried out. Thirty-eight eligible research articles were identified, which examined over 15 candidate genes. Remarkably, no firm conclusions could be drawn from these studies. Thus, in a second step, we conducted meta-analyses using random effects models on those polymorphisms that had previously been investigated in at least three studies. Specifically, data from 11 studies was analysed in three meta-analyses for the following polymorphisms: SLC6A3 3'UTR VNTR (k=6 samples; n=1463 participants), COMT Val158Met SNP (k=7 samples; n=784) and SLC6A4 5-HTTLPR (k=4 samples, n=204). None of these polymorphisms showed a reliable association with response inhibition performance. The methodological and theoretical implications of these findings are discussed, along with recommendations for future research.
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| http://dx.doi.org/10.1016/j.neubiorev.2017.11.009 | DOI Listing |
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