Background: The independent contribution of levodopa exposure and Parkinson's disease (PD) to the risk of polyneuropathy is not established.
Objective: This study investigated whether patients with newly diagnosed PD without previous exposure to antiparkinsonian drugs have higher prevalence of polyneuropathy than the general population.
Methods: Using the UK General Practice Research Database, presence of polyneuropathy in the previous 3 years was assessed.
Results: Of 5089 PD patients and 19,897 controls, polyneuropathy was confirmed in 15 PD patients (0.29% ) and 24 controls (0.12% ). Polyneuropathy prevalence was 2.4-fold higher in PD patients than controls.
Conclusions: In this observational study, PD patients had a higher prevalence of preexisting polyneuropathy that cannot be explained by adverse effects of antiparkinsonian drugs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836410 | PMC |
| http://dx.doi.org/10.3233/JPD-161057 | DOI Listing |
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