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Change in self-determination-related constructs in persons with severe or profound intellectual and multiple disabilities in the context of transitions.
J Intellect Disabil
January 2025
Department of Clinical Child and Family Studies, Faculty of Behavioural and Movement Sciences and LEARN! Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
This study explored the changes in self-determination-related constructs during transitions in the lives of persons with severe or profound intellectual and multiple disabilities. Questionnaires about autonomy support, basic psychological need expressions, and subjective well-being were filled out twice by family caregivers who foresaw an important transition in the near future ( = 40; pre-post design). Average changes in outcomes across a period of 6-13 months were not statistically significant.
View Article and Find Full Text PDFDevelopment of optical microneedle-lens array for photodynamic therapy.
Biomed Microdevices
January 2025
Institute of Industrial Science, The University of Tokyo, Meguro-Ku, 153-8505, Tokyo, Japan.
Recently, photodynamic therapy (PDT) which involves a photosensitizer (PS), a special drug activated by light, and light irradiation has been widely used in treating various skin diseases such as port-wine stain as well as cancers such as melanoma and non-melanoma skin cancers. PDT comprises two general steps: the introduction of PS into the body or a specific spot to be treated, and the irradiation process using a light source with a specific wavelength to excite the PS. Although PDT is gaining great attention owing to its potential as a targeted approach in the treatment of skin cancers, several limitations still exist for practical use.
View Article and Find Full Text PDF"No Matter the Age or Medical Complexity, People Benefit From That Intensity of Exercise": A Mixed-Methods Study Describing Rehabilitation Provider Perceptions of High-Intensity Resistance Training Among Veterans Receiving Post-Acute Care.
J Geriatr Phys Ther
January 2025
VA Eastern Colorado Geriatric Research Education and Clinical Center (GRECC), VA Eastern Colorado Health Care System, Aurora, Colorado.
Background: In skilled nursing facilities (SNFs), i-STRONGER is a novel, high-intensity resistance training approach that incorporates progressive resistance training to promote greater improvements in patient function compared to usual care. To inform large-scale expansion of i-STRONGER as standard-of-care in SNFs, this mixed-methods study assessed rehabilitation providers' perceptions of i-STRONGER and purported needs for its adoption.
Methods: Forty-three rehabilitation providers participated in an 18-week, interactive i-STRONGER training program.
Profiling and bioinformatics analyses of circular RNAs in myocardial ischemia/reperfusion injury model in mice.
World J Cardiol
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Cardiac Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Background: Myocardial ischemia/reperfusion (I/R) injury, which is associated with high morbidity and mortality, is a main cause of unexpected myocardial injury after acute myocardial infarction. However, the underlying mechanism remains unclear. Circular RNAs (circRNAs), which are formed from protein-coding genes, can sequester microRNAs or proteins, modulate transcription and interfere with splicing.
View Article and Find Full Text PDFThe challenge of belonging: Exploring collegiality and incivility in the transition to academia for nurse clinicians.
Appl Nurs Res
February 2025
School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT), Bundoora West Campus, PO Box 71, Bundoora, VIC 3083, Australia. Electronic address:
Background: Registered nurses are ethically and professionally obligated to foster sustainable and respectful workplaces. However, when transitioning to academia, many nurses encounter unexpected challenges, including hierarchical and individualistic environments that contrast with the collaborative ethos of clinical practice.
Method: This qualitative study explored the experiences of 11 registered nurses from six Australian universities as they transitioned into academic roles.
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