AI Article Synopsis
- The skin plays a vital role as a barrier against external pathogens, and dysfunction of this barrier is a major factor in developing allergic skin diseases like atopic dermatitis.
- The article outlines the organization of the skin's physical barrier and its connection to the mechanisms behind these allergic conditions.
- It also details the formation of the stratum corneum barrier through five main components and explores new methods for restoring proper skin barrier function.
Article Abstract
The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation. New approaches to restoring the skin barrier function are also discussed.
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| http://dx.doi.org/10.1016/j.alit.2017.10.002 | DOI Listing |
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