In this study, we modified the surface of bioresorbable electrospun poly-(l-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.
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Article Synopsis
- This study aimed to explore new scaffold geometries for improving the mechanical performance of Poly-L-lactic Acid (PLLA) bioresorbable vascular scaffolds (BVS) using finite element analysis (FEA) and lab experiments.
- Four different scaffold designs were subjected to simulations and tests, focusing on various mechanical properties like crush resistance and radial strength.
- The results revealed that Design B outperformed others in key performance metrics, suggesting new PLLA scaffold geometries could enhance their use in cardiovascular applications.
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