AI Article Synopsis
- * Recent findings indicate that the signaling from these receptors is interconnected and involves several key pathways, including NF-κB and various MAP kinases.
- * To accurately assess the role of signaling molecules in B cell survival, researchers now use inducible gene deletions, which allow a clearer separation of roles in development versus survival compared to earlier methods.
Article Abstract
The number of mature B cells is carefully controlled by signalling from receptors that support B cell survival. The best studied of these are the B cell antigen receptor (BCR) and BAFFR. Recent work has shown that signalling from these receptors is closely linked, involves the CD19 co-receptor, and leads to activation of canonical and non-canonical NF-κB pathways, ERK1, ERK2 and ERK5 MAP kinases, and PI-3 kinases. Importantly, studies show that investigation of the importance of signalling molecules in cell survival requires the use of inducible gene deletions within mature B cells. This overcomes the limitations of many earlier studies using constitutive gene deletions which were unable to distinguish between requirements for a protein in development versus survival.
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| http://dx.doi.org/10.1016/j.ceb.2017.10.002 | DOI Listing |
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